PENITREM A
PENITREM A
CAS: 12627-35-9
Molecular Formula: C37H44ClNO6
PENITREM A - Names and Identifiers
PENITREM A - Physico-chemical Properties
| Molecular Formula | C37H44ClNO6 |
| Molar Mass | 634.2 |
| Density | 1.0241 (rough estimate) |
| Melting Point | 238°C |
| Solubility | Soluble in DMSO (up to 6 mg/ml) |
| Appearance | White solid. |
| Color | Amorphous solid |
| pKa | 13.22±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.6000 (estimate) |
PENITREM A - Risk and Safety
| Risk Codes | 26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | RY7535000 |
| HS Code | 29349990 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 orl-mus: 10 mg/kg 41KEAL -,108,78 |
PENITREM A - Reference Information
| Introduction | penicillins A(Penitrem A), it is a kind of fungal neurotoxin produced by specific Aspergillus (Aspergillus), ergot (Claviceps) and Penicillium (Penicillium), which can inhibit smooth muscle potassium ion channels, for the first time, it was isolated from the moldy diet that caused the neurological symptoms of sheep, which mainly invaded the central nervous system, and caused the animals to tremors, convulsions, and even death. |
| toxicity | Wilson et al. isolated tremor toxin from the feed of sheep poisoning mainly with neurological symptoms, the toxin acts on the dorsal spinal cord, causing increased stress, tremors and convulsions in experimental animals. The dose of penicillins A to induce tremor in mice was 0.25mg/kg body weight, and the LD50 was 1.05 mg/kg by intraperitoneal injection. Tremor toxin is a neurotoxin, in addition, it can cause renal damage. |
| biological activity | Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, it is a selective BK channel antagonist, which has anti-proliferative and anti-invasive effects on a variety of malignant tumors. Penitrem A can stimulate cerebral cortex synaptosomes to increase the spontaneous release of endogenous glutamic acid, GABA and aspartic acid, which can induce tremor syndrome in animals. |
| Target | BK channel |
Last Update：2024-04-09 02:00:02
